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Introduction
SV388 is an immortalized cell line derived from the lymphoblastoid of a chicken that has been widely used in virology, cancer research, and biotechnology. This case study explores the characteristics, applications, and research advancements associated with SV388, highlighting its importance as a model for sabung ayam avian studies.
Background
Identified in the 1970s, SV388 was established from the lymphatic tissue of chickens infected with the reticuloendotheliosis virus (REV). Its transformation into an immortalized cell line was crucial for researchers, as it exhibited properties that allowed for extended culture periods without losing proliferative capacity. The cell line is characterized by its fast growth rate, the ability to form colonies in soft agar, and altered surface markers, making it a robust model for investigating cellular mechanisms of transformation.
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